8.1 | Class: Cold-shock domain factors (TBP) | |
Description: | Class description: A 10-stranded, anti-parallel beta-sheet forms a quasi-symmetric saddle-like structure, where the convex side is backed by four alpha-helices and the concave side exerts mostly hydrophobic interactions with the minor groove of the TATA-box. Binding of TBP imposes a significant kink of the DNA double helix axis. (PMID 10617571, and references cited therein) | |
Aligned domain sequences: | Alignment of TBP sequences Download fasta file of whole DBDs or of repeats. |
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Logo plot: | ![]() Blue: basic residues (KRH); red: acidic residues (DE); purple: amides (QN); black: hydrophobic residues (AVLIPWFM); green: polar (CSTYG) (http://weblogo.berkeley.edu/) |